Murphy Exploration & Production Company, (Murphy EXPRO) is engaged worldwide in crude oil and natural gas exploration and production. Murphy EXPRO is headquartered in Houston, Texas. In 1999, Murphy opened an office in Kuala Lumpur to oversee its E&P activities in Malaysia.

Murphy Oil USA, Inc., (MOUSA) is engaged in refining, marketing and transportation of petroleum products in the United States. It is headquartered in El Dorado at Murphy's corporate offices. MOUSA's refineries are in Meraux, Louisiana, and Superior, Wisconsin.

A division of MOUSA, Murphy USA Marketing Co. operates retail gasoline stations under the Murphy USA® brand across 20 states in the U.S. These are high-volume, low-cost retail gasoline stations, primarily in the parking areas of Wal-Mart Supercenters. The first Murphy USA station was opened in December 1996.

MOUSA also operates a network of 12 Company-owned terminals. These terminals, along with numerous third-party terminals, provide fuel supply to retail and branded wholesale stations throughout 23 states.